Clinical Report: DEFINE Ampoule

The insight

Re-Structuring 
Helps support a firmer-looking skin foundation by caring for the appearance of weakened skin density and resilience.

Refining
Multi-peptides and high-performance active ingredients help refine rough, tired-looking skin texture, while an NAD-based cellular energy formula supports a healthier-looking, more radiant complexion affected by accumulated fatigue.



1. Skin Soothing Clinical Study


A recovery-focused ritual that helps calm visible skin stress
In the human application test of a CELLOUP-EGF-containing product, the skin soothing index improved after both 2 and 4 weeks of use. Measurement images showed a gradual reduction in visible redness, suggesting its potential to help relieve skin irritation and support a calmer-looking skin condition.

CELLOUP-EGF-Containing Product Use
Approximately 6.09% improvement in skin soothing index after 2 weeks
Approximately 8.26% improvement in skin soothing index after 4 weeks
Visible reduction in redness observed through clinical measurement images


2. Moisture Clinical Study


A moisture-supporting ritual that strengthens the skin’s hydration environment
In the human application test, the CELLOUP-EGF-containing product showed a significant increase in the skin moisturizing index after 2 and 4 weeks of use. The improvement became stronger with continued use, indicating potential for helping improve the skin’s moisture retention and overall hydration condition.

CELLOUP-EGF-Containing Product Use
Approximately 13.59% increase in skin moisturizing index after 2 weeks
Approximately 31.07% increase in skin moisturizing index after 4 weeks
Moisture level increased progressively with continued use


3. Pore Appearance Clinical Study


A texture-refining ritual that improves the appearance of pores
In the human application test, the CELLOUP-EGF-containing product improved the skin pore index after 2 and 4 weeks of use. With continued use, pore volume significantly decreased, and image analysis showed a visible tendency toward improved pore appearance and smoother-looking skin texture.

CELLOUP-EGF-Containing Product Use
Approximately 29.06% improvement in skin pore index after 2 weeks
Approximately 44.65% improvement in skin pore index after 4 weeks
Visible pore-volume reduction tendency confirmed through image analysis


4. Skin Texture Clinical Study


A skin-smoothing ritual that supports refined surface texture
In the human application test, the CELLOUP-EGF-containing product improved the skin roughness index after 2 and 4 weeks of use. Continued use showed a decrease in roughness values, while image analysis also suggested a smoother-looking skin surface.

CELLOUP-EGF-Containing Product Use
 Approximately 9.61% improvement in skin roughness index after 2 weeks
 Approximately 15.71% improvement in skin roughness index after 4 weeks
 Visible tendency toward smoother skin texture observed in measurement images


5. Supporting Skin Science Data


Bioactive EGF technology designed for delivery, recovery, and skin-condition support
Beyond the human application test, CELLOUP-EGF showed supportive in-vitro data related to skin cell activity, wound-recovery response, moisture-related gene expression, and cellular penetration. These results help explain why CELLOUP-EGF can be positioned as a bioactive ingredient for skin recovery and condition improvement.

Key Supporting Results
Cell viability increased up to approximately 170% in keratinocytes
Cell viability increased up to approximately 130% in fibroblasts
Wound-healing activity increased up to approximately 200%
HAS-2 expression, related to hyaluronic acid synthesis, increased up to approximately 153%
Cell penetration increased up to approximately 32.4-fold compared with conventional EGF


6. Safety Evaluation

A skin-applicable growth factor ingredient with safety validation
CELLOUP-EGF was evaluated through primary skin irritation, ocular irritation, and phototoxicity testing by an independent laboratory. The material was evaluated as non-irritant to the skin, not classified under UN GHS for ocular irritation, and non-phototoxic.

Safety Results
Non-irritant in primary skin irritation evaluation
Not classified under UN GHS category for ocular irritation
Non-phototoxic under UV exposure condition